2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-175119
    3'-Bromo ANT-dATP sodium
    3'-Bromo ANT-dATP sodium is a fluorescent ribosyl-modified analogue of the purine nucleotide dATP. The maximum excitation/emission wavelengths of 3'-Bromo ANT-dATP sodium in water are approximately 345/425 nm. 3'-Bromo ANT-dATP sodium can be used as a substrate for various enzymes in molecular biology research.
    3'-Bromo ANT-dATP sodium
  • HY-177199
    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid
    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid is a phosphonamide acid that can be used in nucleic acid synthesis.
    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid
  • HY-171578
    3′-Amino-2′,3′-dideoxy-CTP
    3′-Amino-2′,3′-dideoxy-CTP is an analogue of nucleoside triphosphate. 3′-Amino-2′,3′-dideoxy-CTP can selectively inhibit DNA polymerase β.
    3′-Amino-2′,3′-dideoxy-CTP
  • HY-178658
    CTPαS (Sp isomer)
    CTPαS (Sp isomer) is a monomeric raw material that can be used for nucleic acid synthesis.
    CTPαS (Sp isomer)
  • HY-171526
    2′-F-UDP
    2′-F-UDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-F-UDP
  • HY-178569
    DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite
    DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite
  • HY-131736A
    3'-O-Bn-GTP sodium
    3'-O-Bn-GTP (3'-O-Benzyl-5'-O-guanosine triphosphate) sodium (CAP-164) is an analog of GTP. 3'-O-Bn-GTP sodium has a higher stability against esterases.
    3'-O-Bn-GTP sodium
  • HY-W048245
    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol
    		98.74%
    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol
  • HY-178614
    3′-O-Azidomethyl-UTP
    3′-O-Azidomethyl-UTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3′-O-Azidomethyl-UTP
  • HY-178655
    DMTr-2'-O-C6-rA(Bz)-3'-CE-phosphoramidite
    DMTr-2'-O-C6-rA(Bz)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C6-rA(Bz)-3'-CE-phosphoramidite
  • HY-131773
    2-Cl-5'-AMP
    2-Cl-5'-AMP is a 5'-AMP analogue and can be used for receptor mapping research.
    2-Cl-5'-AMP
  • HY-W925610
    5'-DMTr-LNA-N6-Bz-A
    5'-DMTr-LNA-N6-Bz-A is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-DMTr-LNA-N6-Bz-A
  • HY-178532
    3-Deoxy-1,2-O-isopropylidene-α-D-ribofuranose
    3-Deoxy-1,2-O-isopropylidene-α-D-ribofuranose is a monomeric raw material that can be used for nucleic acid synthesis.
    3-Deoxy-1,2-O-isopropylidene-α-D-ribofuranose
  • HY-137701A
    ddATPαS tetrasodium
    ddATPαS tetrasodium is a dideoxynucleotide that can be used for DNA sequencing.
    ddATPαS tetrasodium
  • HY-157093
    Cytidine, 5′-P,P′,P′′,P′′-tetrahydrogen imidotriphosphate
    Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide.
    Cytidine, 5′-P,P′,P′′,P′′-tetrahydrogen imidotriphosphate
  • HY-178660
    DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite
    DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite
  • HY-178554
    GTPαS
    GTPαS is a monomeric raw material that can be used for nucleic acid synthesis.
    GTPαS
  • HY-W113609
    5-Phenyluracil
    5-Phenyluracil is a thymidine phosphorylase inhibitor.
    5-Phenyluracil
  • HY-178587
    dTTPαS
    dTTPαS is a monomeric raw material that can be used for nucleic acid synthesis.
    dTTPαS
  • HY-B0116A
    Stavudine sodium
    Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.
    Stavudine sodium